Your Genes. Your Medications. Personalized.
Discover how your unique genetic makeup affects your response to medications. Get personalized drug recommendations backed by clinical evidence and CPIC guidelines.
From the research
One test. A lifetime of prescriptions.
Researchers at Marshfield Clinic sequenced 300 patients and read through more than 30 years of each person's medical records. They wanted to know how often a pharmacogenomic result, on file from the start, would have mattered.
93%
carried at least one clinically significant variant in a pharmacogene with FDA or CPIC guidance.
80%
were prescribed a medication their genes may have affected, out of 42 different drugs.
1 in 3
carried a loss-of-function CYP2D6 variant. CYP2D6 processes many antidepressants, opioids and heart medications.
Your genes don't change. Your prescriptions will.
A ReasonShield report is a portable, guideline-based record (CPIC, FDA, PharmGKB) that you and every future clinician can use at the moment a drug is prescribed.
Ye Z, Mayer J, Leary EJ, et al. Estimating the efficacy of pharmacogenomics over a lifetime. Front Med. 2023;10:1006743. doi:10.3389/fmed.2023.1006743. Retrospective study of a primarily older, rural cohort of European ancestry; CYP2D6 structural variants were not assessed and clinical outcomes were not formally evaluated.
Comprehensive Pharmacogenomic Analysis
Our platform analyzes your genetic variants to provide actionable insights for medication selection and dosing.
21 Key PGx Genes
Analysis of pharmacogenes including CYP2D6, CYP2C19, CYP2C9, DPYD, TPMT, SLCO1B1, HLA-A, HLA-B, and more that affect drug metabolism.
870+ Medications
Comprehensive drug database with 5,100+ clinical annotations and 2,100+ dosing recommendations based on CPIC, DPWG, and FDA guidelines.
Detailed Reports
Easy-to-understand reports with gene summaries, drug recommendations, and clinical annotations.
PK/PD Classification
Separate pharmacokinetic and pharmacodynamic gene analysis for complete understanding.
HIPAA Compliant
Your genetic data is protected with enterprise-grade security and strict privacy controls.
Provider Portal
Healthcare providers can access patient reports and integrate with existing workflows.
How It Works
Get your personalized PGx report in three simple steps.
Upload Your Data
Upload your VCF file from any genetic testing service (23andMe, Ancestry, clinical labs, etc.)
AI Analysis
Our platform analyzes your genetic variants against clinically validated PGx databases.
Get Your Report
Receive a comprehensive report with personalized drug recommendations you can share with your doctor.
Ready to Personalize Your Medicine?
Join thousands of patients and providers using ReasonShield PGx for better medication decisions.